2024

• Yang HY, et al. Can J Anaesth – The evolution and formalization of anesthesia assistant roles across Canada
• Brenna CTA, et al. Anesthesiology – Repurposing General Anesthetic Drugs to Treat Depression: A New Frontier for Anesthesiologists in Neuropsychiatric Care 
• Orser BA. Anesthesiology – Discovering the Intriguing Properties of Extrasynaptic γ-Aminobutyric Acid Type A Receptors
• Gordon M, et al. Psychiatry Res – Self-harm presentations to hospital trauma centre emergency departments during the first year of the COVID-19 pandemic

2023

• Wang DS, et al. Transl Res – Crosstalk between GABAA receptors in astrocytes and neurons triggered by general anesthetic drugs
• Simkin S, et al. Anesth Analg – The physician anesthesia workforce in Canada from 1996 to 2018: A longitudinal analysis of health administrative data
• Ariza A, et al. STAR Protoc – Cell-surface biotinylation of GABAA receptors in mouse hippocampal slices after sevoflurane anesthesia
• Onodera Y, et al. iScienice – Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern
• Cuninghame S, et al. Br J Anaesth – Effect of inhaled anaesthetics on cognitive and psychiatric outcomes in critically ill adults: a systematic review and meta-analysis
• Orser BA and Wilson R. Rural Remote Health – Rural generalist anesthetists have the expertise to help plan for the anesthesia healthcare needs in their communities
• Khodaei S, et al. BJA Open – Reduced excitatory neurotransmission in the hippocampus after inflammation and sevoflurane anaesthesia
• Simkin S, et al. Hum Resour Health – The anesthesia workforce in Canada: a methodology to identify physician anesthesia providers using health administrative data
• Orser BA, et al. Can J Anaesth – Preventing neuraxial administration of tranexamic acid
• Kim WSH, et al. Bipolar Disord – Proof-of-concept randomized controlled trial of single-session nitrous oxide treatment for refractory bipolar depression: Focus on cerebrovascular target engagement
• Khodaei S, et al. Br J Anaesth – Sevoflurane and lipopolysaccharide-induced inflammation differentially affect γ-aminobutyric acid type A receptor-mediated tonic inhibition in the hippocampus of male mice

2022

• Guo LY, et al. Br J Anaesth – Cognitive deficits after general anaesthesia in animal models: a scoping review
• McVicar JA, et al. Can J Anaesth – No community left behind: advancing rural anesthesia, surgery, and obstetric care in Canada
• Khodaei S, et al. Anesth Analg – The Impact of Inflammation and General Anesthesia on Memory and Executive Function in Mice
• Orser BA and Spadafora SM. Anesth Analg – Competence-Based Training and Immersion Virtual Reality: Paradigm-Shifting Advances in Medical Education
• Orser BA. Anesth Analg – Before the Next Wave: Reducing Viral Infections Among Health Care Workers Performing Tracheal Intubation.
• Iglesias S, et al. Can Fam Physician – Consensus statement on networks for high-quality rural anesthesia, surgery, and obstetric care in Canada
• Orser BA. Can J Anaeseth – In reply: Initiatives to support rural access to anesthesia.
• Chung W, et al. Front Aging Neurosci – GABA_A Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs.
• Ing C, et al. Anesthesiology – Anesthesia and developing brains: unanswered questions and proposed paths forward.
• Orser BA. Anesthesiology – 2020 Severinghaus lecture on translational science: reply.

2021

• Orser BA, Wilson CR, Bainbridge D. Can J Anaesth – Improving anesthesia care and pain medicine in rural Canada: nothing about us without us.
• Orser BA and Jones KA. Anesth Analg – The International Anesthesia Research Society Coronavirus Disease 2019 pandemic scientific advisory board: Supporting a pandemic of positivity.
• Orser BA. Anesthesiology – Anesthesiology: Resetting our sights on long-term outcomes: the 2020 John W. Severinghaus lecture on translational science
• Choi S, et al. BMJ Open – Cognitive Outcomes after DEXmedetomidine sedation in cardiac surgery: CODEX randomised controlled trial protocol
• Brenna CTA, et al. Brain Behav – Cognitive decline among older adults: A hidden preexisting condition and its role in ‘brain-at-risk’ surgical patients
• Manzo MA, Wang DS, et al. Br J Anaesth – Inhibition of a tonic inhibitory conductance in mouse hippocampal neurones by negative allosteric modulators of α5 subunit-containing γ-aminobutyric acid type A receptors: implications for treating cognitive deficits

2020

• Orser BA and Wilson CR. CMAJ – The authors respond to “Nurse anesthesiologists”
• Orser BA and Wilson CR. CMAJ – Canada needs a national strategy for anesthesia services in rural and remote regions
• Wang DS, Terrando N, Orser BA. Br J Anaesth – Targeting microglia to mitigate perioperative neurocognitive disorders
• Dimick MK, et al. Contemp Clin Trials Commun – Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology
• Nanji KC, et al. BMJ Open – Global PRoMiSe (Perioperative Recommendations for Medication Safety): protocol for a mixed-methods study
• Kamble VA, Orser BA, Wilson CR. Can J Anaesth – Developing practice guidelines for anesthesia services in rural Canada: the importance of the family physician perspective
• Orser BA. Anesth Analg – In response
• Orser BA, Wang DS, Lu WY. EBioMedicine – Sedating ventilated COVID-19 patients with inhalational anesthetic drugs
• Orser BA, et al. Can J Anaesth – Locating and repurposing anesthetic machines as intensive care unit ventilators during the COVID-19 pandemic
• Orser BA. Anesth Analg – Recommendations for endotracheal intubation of COVID-19 patients
• Khodaei S, Avramescu S, et al. Crit Care Med –  Inhibiting α5 subunit-containing γ-aminobutyric acid type A receptors attenuates cognitive deficits after traumatic brain injury

2019

• Orser BA and Brochard L. Anesthesiology – In memoriam: Brian Kavanagh, 1962 to 2019
• Orser BA. Anesthesiology – Musings from an unlikely clinician–scientist. 2018 American Society of Anesthesiologists Excellence in Research Award
• Hemmings HC, et al. Trends Pharmacol Sci – Towards a comprehensive understanding of anesthetic mechanisms of action – a decade of discovery
• Yu J, Wang DS, Bonin RP, et al. EBioMedicine – Gabapentin increases expression of δ subunit-containing GABA_A receptors
• Orser BA and Wang DS. Anesthesiology –  GABA_A receptor theory of perioperative neurocognitive disorders
• Orser BA, Ruth WC, Rotstein AJ, et al. Anesth Analg – Improving access to safe anesthetic care in rural and remote communities in affluent countries
• Choi S, et al. BMJ Open – Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area
• O’Leary JD and Orser BA. Lancet – Neurodevelopment after general anaesthesia in infants
• Untereiner A, Abdo S, Bhattacharjee A, Gohil H, et al. FASEB J – GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity
• Orser BA. Can J Anaesth – Anesthesiology in the 21^st century: our science is our destiny

2018

• Berger M, et al. Anesth Analg – Best practices for postoperative brain health – recommendations from the fifth international Perioperative Neurotoxicity Working Group
• Wang DS, Kaneshwaran K, Lei G, et al. Anesthesiology – Dexmedetomidine prevents excessive γ-aminobutyric acid type A receptor function after anesthesia
• Orser BA, et al. Anesth Analg – SmartTots update regarding anesthetic neurotoxicity in the developing brain

2017

• Montandon G et al. Scientific Reports – δ-subunit containing GABA-A receptors modulate respiratory networks
• Avramescu S et al. Lancet – Preventing delirium: beyond dexmedetomidine
• Wang DS et al. N Engl J Med. – Tranexamic acid in patients undergoing coronary-artery surgery
• Lecker I et al. Anesthesiology – High concentrations of tranexamic acid inhibit ionotropic glutamate receptors
• Wang DS et al. Anesthesiology – Ketamine increases the function of  γ-aminobutyric acid type A receptors in hippocampal and cortical neurons
• Mesbah-Oskui L et al. Neurotoxicology and Teratology –  α5 GABA-A receptors elicit autism-like alterations in EEG patterns and sleep-wake behaviors
• Perez-Sanchez J et al. Journal of Neuroscience Research – α5GABAA receptors mediate tonic inhibition in the spinal cord dorsal horn and constrain nociception

2016

• Piantadosi SC et al. Frontiers in Pharmacology – Sex-dependent anti-stress effect of an α5 subunit containing GABA-A receptor positive allosteric modulator
• Walters JL et al. Neurotoxicology – Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats
• Roth SH et al. Anesth Analg – Unlocking the mechanisms of anesthesia
• Avramescu S et al. Anesthesiology – Letter in reply
• Whissell PD et al. Anesth Analg – δGABAA receptors are necessary for synaptic plasticity in the hippocampus: implications for memory behavior
• Zurek AA et al. Ann Clin Transl Neurol. –  α5GABAA receptor deficiency causes autism-like behaviors
• Orser B et al. Lancet – The GAS trial
• Avramescu S et al. Can J Anaesth. – Anesthesia research training: preparing for the future of our speciality
• Lecker I et al. Annals of Neurology – Tranexamic acid-associated seizures: causes and treatment
• Avramescu S et al. Anesthesiology – Inflammation increases neuronal sensitivity to general anesthetics
• Orser BA et al. Anesthesiology – Perioperative Medication Errors: Building Safer Systems

2015

• Nanji KC and Orser BA. Anesth Analg. – Managing Ebola: Lessons Learned from the SARS Epidemic
• Accardi MV, et al. J Neurosci – α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells
• Rappaport BA, et al. N Engl J Med — Anesthetic neurotoxicity–clinical implications of animal models
• McBain CJ, et al. Neuropharmacology —GABAergic signaling in health and disease
• Whissell PD, et al. Neuropharmacology —Altered expression of δGABAA receptors in health and disease

2014

• Zurek AA, et al. J Clin Invest — Sustained increase in α5GABA(A) receptor function impairs memory after anesthesia
• Mesbah–Oskui L, et al. J Neurosci — Thalamic δ-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo
• Whissell PD, et al. Neuropharmacology — Altered expression of δGABA(A) receptors in health and disease
• Penna A, et al. J Neurosci — Hydrogen peroxide increases GABA(A) receptor-mediated tonic current in hippocampal neurons
• Diaz MR, et al. Neuropharmacology — Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats

2013

• Whissell PD, et al. Front Neural Circuits — Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus
• Jevtovic-Todorovic V, et al. Br J Anaesth — Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
• Whissell PD, Rosenweig S, et al. Ann Neurol — γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus
• Lecker I, et al. Br J Anaesth — Potentiation of GABA_A receptor activity by volatile anaesthetics is reduced by α5GABA_A receptor-preferring inverse agonists
• Bonin RP, et al. PLoS One — Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice
• Xiang YY, et al. Anesthesiology — Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells
• Clarke H, et al. Can J Anaesth — Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial
• Orser BA, et al. Can J Anaesth — Review article: improving drug safety for patients undergoing anesthesia and surgery

2012

• Lecker I, et al. J Clin Invest — Tranexamic acid concentrations associated with human seizures inhibit glycine receptors
• Wang DS, et al. Cell Rep — Memory deficits induced by inflammation are regulated by α5-subunit-containing GABA_A receptors
• Clarke H, et al. Anesth Analg — The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis
• Zurek AA, et al. Anesth Analg — Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia
• Yang K, et al. EMBO J — Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases
• Lecker I, et al. Can J Anaesth — “Seizing” the opportunity to understand antifibrinolytic drugs

2011

• Chen X, et al. Int J Physiol Pathophysiol Pharmacol — An anti-coagulation agent Futhan preferentially targets GABA_A receptors in lungepithelia: implication in treating asthma
• Chen X, et al. PLoS One — Functional modifications of acid-sensing ion channels by ligand-gated chloride channels
• Mashour GA, et al. Anesthesiology — Intraoperative awareness: from neurobiology to clinical practice
• Bonin RP, et al. Pain — Pharmacological enhancement of δ-subunit-containing GABA_A receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice
• Wang DS & Orser BA. Can J Anaesth — Inhibition of learning and memory by general anesthetics
• Martin LJ, et al. Behav Brain Res — The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptors
• Li HB, et al. Hippocampus — Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses

2010

• Chen X, et al. Mol Brain — The modulation of TRPM7 currents by nafamostat mesilate depends directly upon extracellular concentrations of divalent cations
• Saab BJ, et al. Anesthesiology — Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708
• Chen X, et al. Eur J Pharmacol — Design and screening of ASIC inhibitors based on aromatic diamidines for combating neurological disorders
• Martin LJ, et al. J Neurosci — α5GABA_A receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory
• Clarke H, et al. Pain Med — Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty
• Chen X, et al. Neuropharmacology — Diarylamidines: high potency inhibitors of acid-sensing ion channels
• Vargas-Caballero M, et al. Neuropharmacology — α5 Subunit-containing GABA_A receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activation

2009

• Martin LJ, et al. Biochem Soc Trans — The physiological properties and therapeutic potential of α5GABA_A receptors
• Martin LJ, et al. Anesthesiology — Etomidate targets α5 γ-aminobutyric acid subtype A receptors to regulate synaptic plasticity and memory blockade
• Sun HS, et al. Nat Neurosci — Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
• Ju YH, et al. J Neurosci Res — Distinct properties of murine α5 γ-aminobutyric acid type A receptors revealed by biochemical fractionation and mass spectroscopy
• Li GH, et al. Int J Physiol Pathophysiol Pharmacol — Reciprocal and activity-dependent regulation of surface AMPA and NMDA receptors in cultured neurons

2008

• Lingard L, et al. Arch Surg — Evaluation of a preoperative checklist and team briefing among surgeons, nurses, and anesthesiologists to reduce failures in communication
• Merali R, et al. Healthc Q — Medication safety in the operating room: teaming up to improve patient safety
• Bonin RP & Orser BA. Pharmacol Biochem Behav — GABA_A receptor subtypes underlying general anesthesia

2007

• Wei WL, et al. Proc Natl Adad Sci — TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations
• Bonin RP, et al. J Neurophysiol — α5GABA_A receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neurons
• Xiang YY, et al. Nat Med — A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
• Li J, et al. Br J Pharmacol — Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels
• Caraiscos VB, et al. Mol Pharmacol — Insulin increases the potency of glycine at ionotropic glycine receptors

 Selected Publications Before 2007

• Cheng VY, et al. Anesthesiology — Gabapentin increases a tonic inhibitory conductance in hippocampal pyramidal neurons
• Cheng VY, et al. J Neurosci — α5GABA_A receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate
• Macdonald DS, et al. J Neurosci — Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src
• Hemmings HC Jr, et al. Trends Pharmacol Sci — Emerging molecular mechanisms of general anesthetic action
• Caraiscos VB, et al. Proc Natl Acad Sci U S A — Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors
• Caraiscos VB, et al. J Neurosci — Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane
• Yeung JY, et al. Mol Pharmacol — Tonically activated GABA_A receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA
• Kotecha SA, et al. Neuron — A D2 class dopamine receptor transactivates a receptor tyrosine kinase to inhibit NMDA receptor transmission
• Bai D, et al. Mol Pharmacol — Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by γ-aminobutyric acid A receptors in hippocampal neurons
• Iihara K, et al. J Neurosci — The influence of glutamate receptor 2 expression on excitotoxicity in Glur2 null mutant mice
• Joo DT, et al. Anesthesiology — Blockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration
• Lei S, et al. Nat Neurosci — Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG
• Lu WY, et al. J Neurosci — In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors
• Bai D, et al. J Neurosci — The general anesthetic propofol slows deactivation and desensitization of GABA_A receptors
• Joo DT, et al. Anesthesiology — Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice
• Lu WY, et al. Nat Neurosci — G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors
• Orser BA, et al. Anesthesiology — Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors
• Wang LY, et al. Nature — Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A
• Orser BA, et al. J Neurosci — Propofol modulates activation and desensitization of GABA_A receptors in cultured murine hippocampal neurons