Chen X, Numata T, Li M, Mori Y, Orser BA, Jackson MF, Xiong ZG, MacDonald JF. (2010) Mol Brain. 3:38. Abstract Concentrations of extracellular divalent cations (Ca2+ and Mg2+) fall substantially during intensive synaptic transmission as well as during some pathophysiological conditions such as epilepsy and brain ischemia. Here we report that a synthetic serine […]
Martin LJ, Zurek AA, Bonin RP, Oh GH, Kim JH, Mount HT, Orser BA. (2011) Behav Brain Res.217(2):379-85. Abstract The precise mechanisms underlying the memory-blocking properties of ethanol are unknown, in part because ethanol targets a wide array of neurotransmitter receptors and transporters. The aim of this study was to determine whether the memory loss caused by […]
Bonin RP, Labrakakis C, Eng DG, Whissell PD, De Koninck Y, Orser BA. (2011) Pain. 152(6):1317-26. Abstract The development of new strategies for the treatment of acute pain requires the identification of novel nonopioid receptor targets. This study explored whether δ-subunit-containing GABAARs (δGABAARs) in neurons of the spinal cord dorsal horn generate a tonic inhibitory conductance […]
Mashour GA, Orser BA, Avidan MS. (2011) Anesthesiology. 114(5):1218-33. Abstract Intraoperative awareness is defined by both consciousness and explicit memory of surgical events. Although electroencephalographic techniques to detect and prevent awareness are being investigated, no method has proven uniformly reliable. The lack of a standard intraoperative monitor for the brain likely reflects our insufficient understanding of consciousness […]
Chen X, Whissell P, Orser BA, MacDonald JF. (2011) PLoS One. 6(7):e21970. Abstract Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (CFTR). Here we show that ASICs were reversibly inhibited by […]
Chen X, Li M, Xiong ZG, Orser BA, Macdonald JF, Lu WY. (2011) Int J Physiol Pathophysiol Pharmacol. 3(4):249-56. Abstract Futhan is a serine protease inhibitor and medicine in the treatment of disseminated intravascular coagulation (DIC) and acute pancreatitis. It is metabolized quickly in vivo. Here we show that Futhan reversibly inhibits NMDA receptors in hippocampal […]
Lecker I, Orser BA, Mazer CD. (2012) Can J Anaesth. 59(1):1-5. Comment on Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. [Can J Anaesth. 2012] Click on link to Pubmed
Zurek AA, Bridgwater EM, Orser BA. (2012) Anesth Analg. 114(4):845-55. Abstract BACKGROUND: General anesthetics cause cognitive deficits that persist much longer than would be expected on the basis of their pharmacokinetics. The cellular mechanisms underlying these postanesthetic cognitive deficits remain unknown. γ-Aminobutyric acid type A (GABAA) receptors are principal targets for most anesthetics. In particular, the […]
Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J. (2012) Anesth Analg. 115(2):428-42. Abstract BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and pregabalin administration in the perioperative period as an adjunct to reduce acute postoperative pain. However, very few clinical trials have examined the use of gabapentin and pregabalin […]
Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA. (2012) Cell Rep. 2(3):488-96. Abstract Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse […]