Perez-Sanchez J, Lorenzo LE, Zurek A, Labrakakis C, Bridgwater E, Orser BA. (2017) Journal of Neuroscience Research 65(6): 1307-1318 Abstract: Neuronal inhibition mediated by GABAA receptors constrains nociceptive processing in the spinal cord, and loss of GABAergic inhibition can produce allodynia and hyperalgesia. Extrasynaptic α5 subunit-containing GABAA receptors (α5GABAA Rs) generate a tonic conductance that inhibits […]

Piantadosi SC, French BJ, Poe MM, timic T, Markovic B, Pabba M, Seney M, Oh H, Orser BA, Savic MM, Cook JM, Sibille E. (2016) Frontiers in Pharmacology 7:446 Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor […]

Walters JL, Chelonis JJ, fogle CM, Orser BA, Paule MG. (2016) Neurotoxicology 56: 159-169 Abstract: Postoperative Cognitive Dysfunction (POCD) is a complication that can occur in the elderly after anesthesia and surgery and is characterized by impairments in information processing, memory, and executive function. Currently, it is unclear whether POCD is due to the effects of surgery, […]

Perez-Sanchez J, Lorenzo Le, Zurek A, Labrakakis C, Bridgwater E, Orser BA, De Koninck Y, Bonin R. (2017) Journal of Neuroscience 95(6): 1307-1318 Abstract Neuronal inhibition mediated by GABAA receptors constrains nociceptive processing in the spinal cord, and loss of GABAergic inhibition can produce allodynia and hyperalgesia. Extrasynaptic α5 subunit-containing GABAA receptors (α5GABAA Rs) generate a tonic conductance […]

Roth SH, Miller KW, Orser BA, Urban BW. (2016) Anesth Analg Click on link to Pubmed

Avramescu S, Wang DS, Orser BA. (2016) Anesthesiology 125(3): 604-605 Click on link to Pubmed

Whissell PD, Avramescu S, Wang DS, Orser BA. (2016) Anesth Analg Abstract: BACKGROUND: Extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that contain the δ subunit (δGABAA receptors) contribute to memory performance. Dysregulation of δGABAA receptor expression, which occurs in some neurological disorders, is associated with memory impairment. Mice lacking δGABAA receptors (Gabrd) exhibit deficits in […]

Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, and Orser BA. (2016) Ann Clin Transl Neurol. 3(5):392-8 Abstract: The prevalence of autism spectrum disorders (ASDs), which affect over 1% of the population, has increased twofold in recent years. Reduced expression of GABAA receptors has been observed in postmortem […]

Orser BA, Evers AS, Suresh S, and Hertz S. (2016) Lancet. 387(10028):1613-4 Comment on: Neurodevelopmental outcome at 2 years of age after general anesthesia and awake-regional anesthesia in infancy (GAS): an international multicentre, randomized controlled trial (Lancet. 2016) Click on link to Pubmed

Lecker I, Wang DS, Whissell PD, Avramescu S, Mazer D and Orser BA. (2015) Annals of Neurology (in press) Abstract Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postoperative seizures. […]