Drs. Fahad Alam, Stephen Choi, and Beverley Orser featured in the Globe and Mail talking about the complexities of anesthesia. Full article can be found here: https://www.theglobeandmail.com/life/health-and-fitness/advsunnybrook/waking-up-to-the-complexities-of-anesthesia/article34720912/
Dr. Stephen Choi from Sunnybrook Health Sciences Centre was mentioned in Science Magazine. Full article can be found here: Science Magazine 2017
The University of Toronto’s student newspaper “The Varsity” published an article on Wednesday discussing how our lab’s current research is working towards preventing anesthesia-related memory deficits: “The Evolution of Anaesthesia” – The Varsity
Following the meeting of the Australian and New Zealand College of Anaesthetists (ANZCA) in Singapore this past week, stories that describe our research were published in the Herald Sun and The Sydney Morning Herald: “Scientists trying to develop new anaesthetics that reduce risk of memory loss” – Herald Sun “Surgery linked to memory loss and […]
Dr. Beverley Orser attended the 2014 Australian and New Zealand College of Anesthetists (ANZCA) annual scientific meeting in Singapore, where she gave a talk about the effects of anesthetics on postoperative cognitive dysfunction (POCD), specifically on memory loss. Dr. Orser was interviewed shortly after to give a recap of the talk and her research: Dr. […]
Mesbah-Oskui L, Penna A, Orser BA, Horner RL (2017) Neurotoxicology and Teratology 61: 115-122 Abstract A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired […]
Avramescu S, Wang DS, Choi S, Orser BA. (2017) Lancet 389(10073): 1009 Click on link to Pubmed
Wang DS, Mazer CD, Orser BA. (2017) N Engl J Med. Click on link to Pubmed
Lecker I, Wang DS, Kaneshwaran K, Mazer CD, Orser BA. (2017) Anesthesiology doi: 10.1097/ALN.0000000000001665. Abstract BACKGROUND: The antifibrinolytic drug tranexamic acid is structurally similar to the amino acid glycine and may cause seizures and myoclonus by acting as a competitive antagonist of glycine receptors. Glycine is an obligatory co-agonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate […]
Wang DS, Penna A, Orser BA. (2017) Anesthesiology 126(4): 666-677 Abstract BACKGROUND: The “dissociative ” general anesthetic ketamine is a well-known N-methyl-D-aspartate receptor antagonist. However, whether ketamine, at clinically relevant concentrations, increases the activity of inhibitory γ-aminobutyric acid (GABA) receptor type A (GABAA) receptors in different brain regions remains controversial. Here, the authors studied the effects […]