Anesthetic neurotoxicity–clinical implications of animal models

Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA. (2015) N Engl J Med. 372(9):796-7.


Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.

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